Milano Centrale is the main railway station of Milan, Italy, and one of the main railway stations in Europe. The station is a railway terminus and was officially inaugurated in 1931 to replace the old central station (1864), which was a transit station and could not handle the new traffic caused by the opening of the Simplon tunnel in 1906.

It is served by high speed lines to Bologna (to Rome and Naples) and Turin, and conventional railways to Bologna, Turin, Venice, Genoa, Domodossola (for the Simplon and Bern), Chiasso (for the Gotthard and Zürich Hauptbahnhof) and Lecco.

There is an open area towards Piazza San Babila on Corso Vittorio Emanuele, onto which the impressive church of San Carlo al Corso looks. It was designed by the Neo-Classical architect, Carlo Amati, 1839-47